Analysis of the curative effect of high nasal flow humidification oxygen therapy in the home oxygen therapy of chronic obstructive pulmonary disease with chronic respiratory failure
CAI Bo1, YU Guangsheng2, QIN Jian1, HUANG Xiaoqing2, ZHANG Yunhui3 ( 1. Clinical college of Dali University, Dali, Yunnan, 671000, China; 2. Department of Respiratory, Guangdong province Shantou
Chaonan Minsheng Hospital, Shantou, Guangdong, 515000, China; 3. Department of Respiratory and Critical Care, Yunnan First People’ s Hospital, Kunming, Yunnan, 650000, China)
Abstract:
Objective To observe and analyze the therapeutic effect of High-flow Nasal Cannula (HFNC) in long-term home oxygen therapy for patients with chronic obstructive pulmonary disease combined with chronic respiratory failure. Methods From March 2019 to August 2019, 87 pa- tients diagnosed with Chronic obstructive pulmonary disease with chronic respiratory failure in the department of respiratory sciences, clinical college of Dali University, Chaonan Minsheng Hospital of Shantou, and the First People’ s Hospital of Yunnan province were selected. These patients which were treated better and discharged from the hospital, were divided into group A (no oxygen therapy intervention group, n=27), group B (conventional nasal catheter oxygen group, n=35) and group C (HFNC group, n=25) according to the way they received oxygen. The patients were followed up for 6 months to observe the changes of the indexs before and after treatment: 6 min walking distance (6MWD), improved medical research society dyspnea scale (MMRC), COPD Assessment Test TM (CAT), arterial blood PaO2, PaCO2, blood routine (hemoglobin, hematocrit), pulmonary artery pressure, pulmonary ventilation function (FEV1, FEV1%pre). Results After treatment, the improvement effects of 6MWD, MMRC and CAT scores in group C were better than those of groups A and B (P＜0.05). The improvement effect of 6MWD and MMRC in group B was better than that of group A (P< 0.05). There was no statistically significant difference in CAT scores between group A and B. Compared with group A, pulmonary artery pressure, FEV1, FEV1%pre of group C improved more significantly after treatment (P＜0.05), group B FEV1%pre was better than group A (P＜0.05),there was no significant difference in pulmonary artery pressure and FEV1, the treatment effect of pulmonary artery pressure and FEV1%pre in group C was sig- nificantly better than that in group B (P＜0.05). After treatment, the treatment effect of PaO2 and PaCO2 in group B and C was significantly better than that of group A (P＜0.05), and the treatment effect of group C was significantly better than that of group B (P＜0.05). Conclusion Long-term home oxygen therapy can significantly improve the quality of life and pulmonary ventilation function inpatients with chronic obstructive pulmonary dis- ease (COPD) combined with chronic respiratory failure. HFNC has a greater advantage than simply using low flow oxygen.
Key words: High-flow Nasal Cannula; Home oxygen therapy; Chronic obstructive pulmonary disease; Chronic respiratory failure
Source: Contemporary Medicine，Jan.2021，Vol.27 No.1 Issue No.588